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Silexion starts GMP manufacturing of SIL204 and gets Phase 2/3 trial approval for pancreatic cancer.

Company Fundamentals
13 May 2026
Silexion Therapeutics Corp
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Bullish
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Silexion Therapeutics has begun Good Manufacturing Practice (GMP) clinical batch production of SIL204, a next-generation siRNA therapy targeting mutated KRAS in pancreatic cancer. The Helsinki Ethics Committee at Tel Aviv Sourasky Medical Center approved the planned Phase 2/3 trial, marking a key clinical milestone. Manufacturing is done in collaboration with Catalent at their European facility, supporting the upcoming trial that will test SIL204 combined with chemotherapy. This progress advances Silexion closer to initiating patient dosing and clinical evaluation of SIL204's effectiveness in locally advanced pancreatic cancer.

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