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Ziihera plus chemo shows 27-month median survival, beating trastuzumab in advanced HER2+ gastroesophageal cancer

Company Fundamentals
23 Oct 2026
PRNewsWire
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Bullish
Ziihera plus chemo shows 27-month median survival, beating trastuzumab in advanced HER2+ gastroesophageal cancer

Jazz Pharmaceuticals announced that Ziihera (zanidatamab) combined with chemotherapy, with or without tislelizumab, significantly improves overall survival in HER2-positive advanced gastroesophageal adenocarcinoma. The Phase 3 HERIZON-GEA-01 trial showed a median overall survival of 27 months for Ziihera plus tislelizumab and chemotherapy, compared to 19.6 months with trastuzumab plus chemotherapy, reducing death risk by 24-35%. Nearly 40% of patients treated with Ziihera plus tislelizumab and chemotherapy were alive at three years, marking a new standard for first-line treatment. The regimens were recently FDA-approved and included in clinical guidelines, with manageable safety profiles confirmed by longer follow-up.

Ziihera® (zanidatamab-hrii) combinations in advanced gastroesophageal adenocarcinoma provide context for health sector trading as of Oct 23, 2026 21:32 WIB. On Pluang, out of 150 priced Health-sector US stocks, 19 rose and 130 fell today. Notable movers include TNGX at USD 22.95 with a -17.81% change and 100% buy order activity, NUWE at USD 0.44 down 9.86% with 100% buy orders, and INO at USD 0.91 up 8.05% with 73% sell orders. The most notable figure is the 130 stocks that declined.

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