US equity markets show signs of speculative excess with record margin debt at $1.4 trillion and leveraged ETF assets at $198 billion. The tech-heavy Nasdaq experienced its largest weekly drop since April 2025, reflecting a pullback in the most speculative sectors. Market leadership has narrowed, with major tech firms losing $5 trillion in market cap due to rising capital expenditures and declining free cash flow. These factors point to heightened market risk and caution for future returns after a long rally.
AbbVie announced positive topline results from the Phase 3 EPCORE DLBCL-4 trial, where epcoritamab combined with lenalidomide significantly improved progression-free survival in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBC...
A new study analyzing nearly 68,000 US patients found that adoption of adalimumab biosimilars increased significantly after formulary changes, but over 16% of those who switched from Humira reverted back to the original drug. The research highlights ...
The European Medicines Agency's CHMP has given a positive opinion recommending approval of AbbVie's upadacitinib for treating severe alopecia areata in adults and adolescents. This recommendation follows Phase 3 trial data showing significant hair re...
The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has given a positive opinion recommending upadacitinib for treating adult and adolescent patients with non-segmental vitiligo, a chronic autoimmune skin disease. Th...
The JPMorgan Equity Premium Income ETF (JEPI) pays monthly distributions currently yielding about 8.3%, but the payment amount fluctuates due to its strategy of selling out-of-the-money call options, which generate premiums that depend on market vola...
