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Combination of brenetafusp and KIMMTRAK shows 70% two-year survival in metastatic uveal melanoma Phase 1/2 trial

Company Fundamentals
06 Nov 2026, 19:00 WIB
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Combination of brenetafusp and KIMMTRAK shows 70% two-year survival in metastatic uveal melanoma Phase 1/2 trial

Immunocore's Phase 1/2 trial data reveal that combining brenetafusp with KIMMTRAK in first-line metastatic uveal melanoma patients achieved a 70% estimated two-year overall survival rate, with median overall survival not reached after 29 months. The combination showed a 29% overall response rate and a 71% disease control rate, with manageable safety profiles. This is the first evidence of clinical activity from two T cell engagers combined in a solid tumor, prompting plans for a Phase 2/3 randomized trial to further evaluate this promising treatment option.

Immunocore's Phase 1/2 trial data show a 70% estimated two-year overall survival rate for metastatic uveal melanoma patients treated with brenetafusp plus KIMMTRAK. For readers following the health sector, here is Pluang's market snapshot as of Nov 06, 2026 23:12 WIB: out of 150 priced US health stocks, 76 rose and 72 fell. Notable movers include CGC at USD 0.61 with a -9.72% change and 100% sell order activity, DNA at USD 10.82 with +8.63% and 100% buy order activity, and SMMT at USD 15.26 with +7.51% and balanced buy/sell activity.

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