When trading Crypto Futures, can I set TP and SL separately (or vice versa)?

Yes, you can set TP and SL separately. And as long as you have a contract position in your portfolio, you can also create TP and SL without having to be linked to a buy order first because both will be created as Independent orders. Conversely, you can also create/set TP and SL simultaneously, which is known as the One-Cancels-the-Other (OCO) pair.