Tempus AI vs Vanguard S&P 500 ETF — how do they compare? Tempus AI trades at $49.18 (market cap $8.69B), while Vanguard S&P 500 ETF trades at $687.4. The key difference: Vanguard S&P 500 ETF is trading nearer its 52-week high, Tempus AI nearer its low. Which is the better fit depends on your goals.
| TEM | VOO | |
|---|---|---|
Market Cap | $8.69B | — |
Sector | Broad Market / Factor | Broad Market / Factor |
52-Week High | $103.25 | $698.29 |
52-Week Low | $42.37 | $571.45 |
Enterprise Value | $9.37B | — |
Signals from Pluang's Aura AI — not financial advice
Tempus AI (TEM) trades at $48.41, down 7.74% amid market reaction to its $1.5 billion acquisition of Personalis. The stock shows bearish technical signals with negative moving averages and oversold RSI levels. Fundamentally, the company maintains strong revenue growth ($1.27B in 2025) but faces significant losses (-$245M net income) and negative margins. Recent news highlights strategic expansion in cancer diagnostics through AI-driven platforms.
Despite analyst optimism (61.5% buy ratings, $68.50 target), TEM faces execution risks from the major acquisition and persistent profitability challenges. The stock's current discount to target offers potential upside if integration succeeds, but high cash burn and competitive pressures require careful monitoring for investors considering entry at these levels.
No Aura AI signal available yet.
Trailing returns across standard periods
Latest headlines on both assets
Tempus AI Inc is a technology company. It has built the Tempus Platform, which comprises both a technology platform to free healthcare data from silos and an operating system to make the resulting data useful. Its Intelligent Diagnostics use AI, including generative AI, to make laboratory tests more accurate, tailored, and personal.
Read more on TEM →VOO is a foundational ETF that tracks the S&P 500 Index, providing exposure to 500 of the largest and most established companies in the United States. Renowned for its ultra-low expense ratio and tax efficiency, it serves as a core building block for long-term investors seeking to capture the total return of the U.S. large-cap market in a single, highly liquid vehicle.
Read more on VOO →