Tempus AI vs Vanguard S&P 500 ETF — how do they compare? Tempus AI trades at $70.06 (market cap $12.58B), while Vanguard S&P 500 ETF trades at $715.23 (market cap $1.80T). The key difference: Vanguard S&P 500 ETF is far larger — about 143.1× Tempus AI's market cap, and Vanguard S&P 500 ETF is trading nearer its 52-week high, Tempus AI nearer its low. Which is the better fit depends on your goals — on Pluang, investors hold Tempus AI for 22 Days and Vanguard S&P 500 ETF for 55 Days on average.
| TEM | VOO | |
|---|---|---|
Market Cap | $12.58B | $1.80T |
Volume | 7,444,569 | 4,722,271 |
Sector | Broad Market / Factor | Broad Market / Factor |
52-Week High | $99.28 | $716.17 |
52-Week Low | $41.55 | $580.93 |
Typical Hold Time | 22 Days | 55 Days |
Enterprise Value | $13.21B | — |
Signals from Pluang's Aura AI — not financial advice
Tempus AI (TEM) trades at $72.15, up 2.65% today, with a bullish technical signal and strong analyst support. The stock shows recent earnings beats but remains unprofitable, with a net income margin of -17.77% for 2026. Positive developments include FDA clearance for an AI product and expanded data partnerships, fueling investor optimism in the healthtech sector.
Outlook is cautiously optimistic given growth potential in AI-driven diagnostics, but high valuation (P/S 8.61) and persistent losses pose risks. Upside hinges on revenue scaling and path to profitability, with a consensus price target of $72.60 suggesting limited near-term gains from current levels.
VOO trades at $713.62, down slightly by 0.11% with a bullish technical signal from moving averages. The ETF shows neutral momentum oscillators with RSI at 68.50 suggesting mild overbought conditions. Recent news highlights VOO's role in long-term wealth building through capital growth rather than dividends, with one article positioning it as a recession-resistant holding.
VOO offers diversified exposure to S&P 500 companies with strong institutional backing. Key risks include market volatility from interest rate uncertainty and potential earnings growth slowdown from 35% to 15% in 2027. The ETF remains a core holding for long-term investors despite short interest increasing 46.9% in September.
Trailing returns across standard periods
What Pluang investors did over the last 30 days
Latest headlines on both assets
Tempus AI Inc is a technology company. It has built the Tempus Platform, which comprises both a technology platform to free healthcare data from silos and an operating system to make the resulting data useful. Its Intelligent Diagnostics use AI, including generative AI, to make laboratory tests more accurate, tailored, and personal.
Read more on TEM →VOO is a foundational ETF that tracks the S&P 500 Index, providing exposure to 500 of the largest and most established companies in the United States. Renowned for its ultra-low expense ratio and tax efficiency, it serves as a core building block for long-term investors seeking to capture the total return of the U.S. large-cap market in a single, highly liquid vehicle.
Read more on VOO →