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X4 Pharmaceuticals advances Phase 3 trial for oral PCN therapy with FDA approval potential by 2028-29

Market News
29 Oct 2026, 23:30 WIB
GlobeNewsWire
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Bullish
X4 Pharmaceuticals advances Phase 3 trial for oral PCN therapy with FDA approval potential by 2028-29

X4 Pharmaceuticals is progressing its Phase 3 4WARD trial for mavorixafor, an oral treatment for primary chronic neutropenia (PCN), aiming to complete enrollment by Q4 2026. The company plans a Phase 2b 4STEPS trial in Q1 2027 to test reducing G-CSF doses with mavorixafor. Topline data from both trials are expected in Q1 2028, with potential FDA approval by late 2028 or early 2029. This therapy addresses a significant unmet need in PCN, a rare blood disorder with limited treatment options, and targets an estimated U.S. patient population of 15,000 to 30,000.

X4 Pharmaceuticals' clinical progress in primary chronic neutropenia provides context for health sector activity on Pluang. For readers following health stocks, 106 of 150 US health-sector stocks rose while 44 fell. Notable movers as of Oct 30, 2026 03:11 WIB include HLN at USD 8.58 with 0% Sell / 100% Buy order activity, CTXR at USD 0.60 with 100% Sell / 0% Buy, and WGS at USD 71.25 with 0% Sell / 100% Buy.

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