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Septerna selects SEP-204 for Graves' disease and TED treatment, plans Phase 1 trial in early 2027

Market News
04 Nov 2026, 15:00 WIB
GlobeNewsWire
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Bullish
Septerna selects SEP-204 for Graves' disease and TED treatment, plans Phase 1 trial in early 2027

Septerna, Inc. announced SEP-204 as its lead candidate for treating Graves' disease and thyroid eye disease (TED). SEP-204 is an oral drug that inhibits the thyroid-stimulating hormone receptor (TSHR), showing promising preclinical results including normalization of thyroid hormone levels and reduction of symptoms in animal models. The drug is expected to support once-daily dosing and is set to enter Phase 1 clinical trials in healthy volunteers in early 2027. This development could offer a new treatment option addressing the root cause of these autoimmune diseases, which current therapies do not fully target.

Septerna's announcement of SEP-204 as a development candidate for Graves' disease and thyroid eye disease provides context for health sector activity. For readers following health stocks, here is Pluang's market snapshot as of Nov 04, 2026 18:41 WIB: out of 150 priced US health-sector stocks, 118 rose and 24 fell. Notable movers include OSCR (Oscar Health Inc) at USD 34.95 with a 7.84% increase and Pluang order activity showing 16% Sell / 84% Buy, RVTY (Revvity Inc) at USD 173.82 up 6.32% with 0% Sell / 100% Buy, and NUVB (Nuvation Bio Inc. Class A) at USD 4.98 up 6.18%.

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