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Sefaxersen cuts proteinuria by 43% in IgA nephropathy patients, showing promise to slow kidney disease progression.

Company Fundamentals
23 Oct 2026
GlobeNewsWire
View Source
Bullish
Sefaxersen cuts proteinuria by 43% in IgA nephropathy patients, showing promise to slow kidney disease progression.

Roche announced that its investigational drug sefaxersen significantly reduced proteinuria by 43.1% compared to placebo in a phase III trial involving patients with IgA nephropathy, a chronic kidney disease. Proteinuria reduction is linked to better long-term kidney function, making this a meaningful clinical outcome. Sefaxersen works by inhibiting complement factor B, potentially slowing disease progression and reducing kidney inflammation. The drug is designed for once-monthly self-injection, and the ongoing study will continue to assess kidney function over two years, aiming for regulatory approval and patient access soon.

Roche's interim phase III data on sefaxersen offers context alongside Pluang's health sector snapshot. As of Oct 24, 2026 00:21 WIB, 47 of 150 health stocks rose while 103 fell. Notable movers include INO at USD 0.91 with a +8.48% change and CTXR at USD 0.40 with a +7.87% change.

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