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PAS-004 shows prolonged stable disease and good safety in advanced cancer Phase 1 trial

Market News
23 Oct 2026
GlobeNewsWire
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Bullish
PAS-004 shows prolonged stable disease and good safety in advanced cancer Phase 1 trial

Pasithea Therapeutics announced positive Phase 1 clinical data for PAS-004, a new oral MEK inhibitor, showing prolonged stable disease in heavily pre-treated advanced cancer patients, including those with BRAF V600E mutations resistant to prior therapies. Four patients remained on treatment for over 300 days, with two exceeding 500 days. The drug demonstrated a favorable safety profile with no severe treatment-related adverse events or discontinuations, and a pharmacokinetic profile supporting once-daily dosing. These results, presented at ESMO Congress 2026, suggest PAS-004 could offer durable benefit and tolerability for patients with MAPK pathway-driven tumors and potentially chronic conditions like neurofibromatosis type 1.

Pasithea Therapeutics' positive Phase 1 clinical data for PAS-004 provides context for health sector investors. For readers following health stocks, here is Pluang's market snapshot as of Oct 23, 2026 20:21 WIB: out of 150 priced health-sector US stocks tradable on Pluang, 28 rose and 119 fell today. Notable movers include BTSG at USD 60.01 with a -1.40% change and a typical hold time of 14 days, DYN at USD 15.55 down -1.40% with 100% sell order activity and a 4-day hold time, and INO at USD 0.85 up 1.32% with 73% sell and 27% buy order activity and a 43-day hold time.

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