Korro Bio announced that its experimental drug KRRO-111 demonstrated best-in-class preclinical results by effectively editing RNA to restore functional protein and reduce toxic protein in mouse models of Alpha-1 Antitrypsin Deficiency (AATD). The drug showed over 95% RNA editing, increased beneficial protein levels sixfold, and reduced harmful liver protein by up to 95%, addressing both lung and liver disease manifestations. KRRO-111 is administered subcutaneously and is expected to enter clinical trials with a regulatory submission planned for the first half of 2027. This advancement could offer a transformative treatment for AATD patients, who currently have limited therapy options.
Korro Bio's KRRO-111 preclinical data is the subject, with Pluang's Health sector market data providing context. Of 150 priced Health-sector US stocks tradable on Pluang, 68 rose and 75 fell today. TWST was priced at USD 142.65 with a 1-day change of -4.35% and Pluang order activity of 7% Sell / 93% Buy, SMMT was at USD 15.23 with a -3.79% change, and RXRX was at USD 3.51 with a -3.57% change and 0% Sell / 100% Buy order activity, as of Oct 22, 2026 18:01 WIB.
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