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Dynamic PD-L1 changes on immune cells linked to survival in metastatic breast cancer immunotherapy

Market News
23 Oct 2026
GlobeNewsWire
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Bullish
Dynamic PD-L1 changes on immune cells linked to survival in metastatic breast cancer immunotherapy

BriaCell Therapeutics presented findings at ESMO 2026 showing that changes in PD-L1 expression on circulating cancer-associated macrophage-like cells (CAMLs) correlate with progression-free and overall survival in metastatic breast cancer patients undergoing immunotherapy. The pooled analysis of 111 heavily pretreated patients revealed that PD-L1 levels after treatment initiation, rather than baseline levels, better predict clinical outcomes. These results support further research into CAML PD-L1 as a biomarker to guide immunotherapy decisions, including BriaCell's Bria-IMT regimen, which is currently in a pivotal Phase 3 trial. Positive Phase 2 data and FDA Fast Track designation highlight the potential impact on metastatic breast cancer treatment.

BriaCell's metastatic breast cancer biomarker research is the subject, with Pluang's Health sector data providing market context. As of Oct 23, 2026 17:41 WIB, 42 of 150 Health-sector US stocks rose while 97 fell. Notable movers include NUWE at USD 0.53 with a 7.63% gain and 100% buy order activity, and TNGX at USD 29.86 up 6.91%, both with strong buy interest on Pluang.

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