Upstart Holdings Inc vs State Street SPDR S&P Biotech ETF — how do they compare? Upstart Holdings Inc trades at $24.2 (market cap $2.35B), while State Street SPDR S&P Biotech ETF trades at $154.35 (market cap $10.11B). The key difference: State Street SPDR S&P Biotech ETF is far larger — about 4.3× Upstart Holdings Inc's market cap, and State Street SPDR S&P Biotech ETF is trading nearer its 52-week high, Upstart Holdings Inc nearer its low. Which is the better fit depends on your goals — on Pluang, investors hold Upstart Holdings Inc for 39 Days and State Street SPDR S&P Biotech ETF for 37 Days on average.
| UPST | XBI | |
|---|---|---|
Market Cap | $2.35B | $10.11B |
Volume | 4,203,337 | 12,903,266 |
Sector | Financials | Broad Market / Factor |
52-Week High | $52.74 | $169.55 |
52-Week Low | $22.81 | $104.99 |
Typical Hold Time | 39 Days | 37 Days |
Enterprise Value | $3.88B | — |
Signals from Pluang's Aura AI — not financial advice
Upstart Holdings trades at $24.24, up 0.9% with a bearish technical signal despite recent earnings misses. The company achieved profitability in 2025 with $1.02B revenue and $53.6M net income, though cash flow from operations remains negative at -$147.7M. Recent news highlights partnership expansions into HELOC and auto lending while the stock faces pressure from broader consumer lending sector weakness.
Upstart's AI lending platform shows revenue growth potential but faces execution risks amid volatile credit markets. Analyst consensus targets $39.50 (63% upside) with mixed ratings, while high P/E of 46.5 suggests premium valuation. The key risk remains the company's loan syndication model during economic downturns.
XBI trades at $153.34, up 2.07% today, but faces bearish technical signals with 17 sell indicators versus 4 buys. The ETF's modified equal-weight structure provides exposure to over 150 biotech companies, benefiting from recent M&A activity and positive clinical trial catalysts. Current price sits near resistance at $154, with support at $147.
Biotech sector optimism is growing with cancer vaccine breakthroughs and improved capital access, though XBI's 0.35% expense ratio is higher than broader healthcare ETFs. Key risks include sector volatility and regulatory uncertainty, while analyst consensus remains neutral with 100% hold rating.
Trailing returns across standard periods
What Pluang investors did over the last 30 days
Latest headlines on both assets
Upstart Holdings Inc provides credit services. The company provides a proprietary, cloud-based, artificial intelligence lending platform. The platform aggregates consumer demand for loans and connects it to the network of Upstart AI-enabled bank partners. The revenue of the company is primarily comprised of fees paid by banks.
Read more on UPST →XBI is an equal-weighted ETF that tracks the U.S. biotechnology segment. It provides diversified exposure to small, mid, and large-cap biotech firms involved in drug discovery and medical research, such as Moderna and Exact Sciences.
Read more on XBI →