Twist Bioscience Corp vs Union Pacific Corporation — how do they compare? Twist Bioscience Corp trades at $124.23 (market cap $7.72B), while Union Pacific Corporation trades at $292.86 (market cap $173.99B). The key difference: Union Pacific Corporation is far larger — about 22.5× Twist Bioscience Corp's market cap, and Union Pacific Corporation pays a 1.94% dividend while Twist Bioscience Corp pays none. Which is the better fit depends on your goals.
| TWST | UNP | |
|---|---|---|
Market Cap | $7.72B | $173.99B |
Sector | Health | Industrials |
52-Week High | $124.88 | $307.32 |
52-Week Low | $24.16 | $214.91 |
Enterprise Value | $7.65B | $203.04B |
Dividend Yield | — | 1.94% |
Signals from Pluang's Aura AI — not financial advice
Twist Bioscience (TWST) trades at $123.76, down 0.9% on the day, with a bullish technical signal from moving averages but bearish oscillators. Revenue growth is strong, with 2025 revenue at $376.57 million, though the company remains unprofitable with a net income margin of -31.66%. Recent news highlights an upsized $300 million public offering and an analyst upgrade, contributing to positive sentiment.
The outlook is mixed: robust revenue growth and high analyst buy ratings (78.57%) support upside potential, but persistent losses, negative cash flow, and high valuation ratios pose significant risks. Investors should weigh the growth trajectory against the path to profitability and cash burn concerns.
Union Pacific (UNP) trades at $293.85, up 0.55% with neutral technical signals. The company demonstrates strong fundamentals with Q2 2026 EPS beating estimates at $3.41 versus $3.26 expected, marking the second consecutive quarterly beat. Revenue growth of 12% year-over-year and improved operating efficiency support management's raised full-year EPS guidance. The stock maintains robust profitability metrics including 28.85% net margin and 39.7% ROE, though valuation multiples remain elevated with P/E at 23.71.
Outlook remains positive with analyst consensus price target of $334.33 representing 14% upside potential. Key catalysts include service-led growth driving margin expansion and the pending Norfolk Southern merger offering strategic benefits. Risks include high fuel costs, regulatory scrutiny of the merger, and macroeconomic pressures on freight volumes. Institutional ownership trends show continued accumulation by major funds.
Trailing returns across standard periods
Latest headlines on both assets
Twist Bioscience Corp is a synthetic biology company. It develops a disruptive DNA synthesis platform to industrialize the engineering of biology. The company's DNA synthesis platform utilizes a proprietary semiconductor-based synthetic DNA manufacturing process that synthesizes DNA on silicon instead of on traditional well plastic plates to enable the production of high-quality synthetic DNA faster and affordable as well as overcomes inefficiencies. Powering cost-effective, rapid high-throughput synthesis, it enables researchers to rapidly realize opportunities ahead. Geographically, it derives a majority of revenue from the United States.
Read more on TWST →Omaha, Nebraska-based Union Pacific is the largest public railroad in North America. Operating on more than 30,000 miles of track in the western two thirds of the U.S., UP generated roughly $22 billion of revenue in 2021 by hauling coal, industrial products, intermodal containers, agriculture goods, chemicals, and automotive goods. UP owns about one fourth of Mexican railroad Ferromex and derives about 10% of its revenue hauling freight to and from Mexico.
Read more on UNP →