Compare S&P500 ETF (SPY) vs Twist Bioscience Corp (TWST) Price & Performance
Price performance (Past 24H)
Key statistics
Key statistics
S&P500 ETF vs Twist Bioscience Corp — how do they compare? S&P500 ETF trades at $748.43, while Twist Bioscience Corp trades at $94.18 (market cap $5.45B). Which is the better fit depends on your goals.
| SPY | TWST | |
|---|---|---|
52-Week High | $759.55 | $102.88 |
52-Week Low | $621.75 | $24.16 |
Market Cap | — | $5.45B |
Sector | — | Health |
Enterprise Value | — | $5.37B |
Aura AI Summary
Signals from Pluang's Aura AI — not financial advice
Aura AI Summary
Signals from Pluang's Aura AI — not financial advice
SPY trades at $742.21, down 0.13% with a bearish technical outlook. The S&P 500 index faces pressure, declining 1.6% last week and trading below its 50-day moving average. Recent news highlights concerns about market concentration in tech stocks and elevated valuations, though some analysts see potential for continued gains. A dividend of $1.90 is scheduled for July 2026.
The ETF's outlook is mixed amid technical weakness and valuation debates. While earnings season shows strength, market concentration and fee comparisons with sister funds present risks. The bearish technical signal suggests near-term caution, though long-term index exposure remains a core portfolio strategy for many investors.
Twist Bioscience (TWST) trades at $87.41, down 6.86% today, with a bullish technical outlook despite recent earnings misses. The company shows strong revenue growth from $204M in 2022 to $377M in 2025, though it remains unprofitable with a -19.85% net margin. Analyst consensus is strongly bullish with 11 buy ratings and a $91.63 price target, while recent news highlights AI-driven drug discovery collaborations and upcoming Q3 earnings.
The stock presents growth potential through expanding synthetic biology applications and AI partnerships, but carries significant risk from persistent losses, negative cash flow, and high valuation multiples (P/S 13.94). Investors should weigh the company's innovation trajectory against its path to profitability amid competitive biotech pressures.
Returns comparison
Trailing returns across standard periods
Returns comparison
Trailing returns across standard periods
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Latest headlines on both assets
Top news
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About S&P500 ETF
The ETF is designed to track the performance of the securities and the stocks in the S&P 500 Index. To maintain the composition and weightings, the advisor adjusts the ETF from time to time to conform to periodic changes in the index target.
Read more on SPY →About Twist Bioscience Corp
Twist Bioscience Corp is a synthetic biology company. It develops a disruptive DNA synthesis platform to industrialize the engineering of biology. The company's DNA synthesis platform utilizes a proprietary semiconductor-based synthetic DNA manufacturing process that synthesizes DNA on silicon instead of on traditional well plastic plates to enable the production of high-quality synthetic DNA faster and affordable as well as overcomes inefficiencies. Powering cost-effective, rapid high-throughput synthesis, it enables researchers to rapidly realize opportunities ahead. Geographically, it derives a majority of revenue from the United States.
Read more on TWST →
