O'Reilly Automotive Inc. Common Stock vs Twist Bioscience Corp — how do they compare? O'Reilly Automotive Inc. Common Stock trades at $86.07 (market cap $69.58B), while Twist Bioscience Corp trades at $161.66 (market cap $10.08B). The key difference: O'Reilly Automotive Inc. Common Stock is far larger — about 6.9× Twist Bioscience Corp's market cap, and Twist Bioscience Corp is trading nearer its 52-week high, O'Reilly Automotive Inc. Common Stock nearer its low. Which is the better fit depends on your goals.
| ORLY | TWST | |
|---|---|---|
Market Cap | $69.58B | $10.08B |
Volume | 4,819,072 | 4,229,037 |
Sector | Consumer Cyclical | Health |
52-Week High | $103.05 | $205.00 |
52-Week Low | $82.73 | $25.45 |
Enterprise Value | $78.90B | $10.01B |
Typical Hold Time | — | 27 Days |
Signals from Pluang's Aura AI — not financial advice
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TWST trades at $155.65, down 6.78% over 24 hours, with a bearish technical signal and negative cash flows. Revenue growth is strong, reaching $377M in 2025, but the company remains unprofitable with a net income margin of -31.66%. Recent news highlights its role in Eli Lilly's AI-driven drug discovery platform, boosting sentiment despite earnings misses.
The outlook is mixed: analyst consensus is bullish with a $145.20 price target, but high valuation multiples and persistent losses pose risks. Investment opportunity hinges on AI partnerships driving future profitability, while execution risks and cash burn require careful monitoring.
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O'Reilly Automotive sells automotive aftermarket parts, tools, supplies, equipment, and accessories. It serves both professional service providers and do-it-yourself customers through its store network.
Read more on ORLY →Twist Bioscience Corp is a synthetic biology company. It develops a disruptive DNA synthesis platform to industrialize the engineering of biology. The company's DNA synthesis platform utilizes a proprietary semiconductor-based synthetic DNA manufacturing process that synthesizes DNA on silicon instead of on traditional well plastic plates to enable the production of high-quality synthetic DNA faster and affordable as well as overcomes inefficiencies. Powering cost-effective, rapid high-throughput synthesis, it enables researchers to rapidly realize opportunities ahead. Geographically, it derives a majority of revenue from the United States.
Read more on TWST →