Compare Ionis Pharmaceuticals Inc. Common Stock (IONS) vs Vanguard S&P 500 ETF (VOO) Price & Performance

Ionis Pharmaceuticals Inc. Common StockTrade

Vanguard S&P 500 ETFTrade

Price performance (Past 24H)

Key statistics

Ionis Pharmaceuticals Inc. Common Stock vs Vanguard S&P 500 ETF — how do they compare? Ionis Pharmaceuticals Inc. Common Stock trades at $43.32 (market cap $7.10B), while Vanguard S&P 500 ETF trades at $705.69 (market cap $1.80T). The key difference: Vanguard S&P 500 ETF is far larger — about 253.5× Ionis Pharmaceuticals Inc. Common Stock's market cap, and Vanguard S&P 500 ETF is trading nearer its 52-week high, Ionis Pharmaceuticals Inc. Common Stock nearer its low. Which is the better fit depends on your goals — on Pluang, investors hold Ionis Pharmaceuticals Inc. Common Stock for 0 Days and Vanguard S&P 500 ETF for 57 Days on average.

	IONS	VOO
Market Cap	$7.10B	$1.80T
Volume	2,027,457	6,187,754
Sector	Health	Broad Market / Factor
52-Week High	$86.50	$716.17
52-Week Low	$42.38	$580.93
Typical Hold Time	0 Days	57 Days
Enterprise Value	$6.66B	—

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Aura AI Summary

Signals from Pluang's Aura AI — not financial advice

Ionis Pharmaceuticals Inc. Common Stock

No Aura AI signal available yet.

Vanguard S&P 500 ETF

VOO trades at $715.14 with minimal daily movement (-0.01, -0.0%). The ETF shows strong technical momentum with bullish moving averages and neutral oscillators, while trading near pivot point resistance. Recent news highlights VOO's role in long-term wealth building through S&P 500 exposure, with discussions on dividend strategies and recession resilience.

VOO offers diversified exposure to the S&P 500 with strong institutional backing. Key risks include market volatility and interest rate sensitivity, but its low-cost structure and broad market coverage provide stability. Short interest increased 46.9% in September (Defense World, 2026-10-03), warranting monitoring of bearish sentiment shifts.

Aura AI is an analytical signal, not financial advice — do your own research.

Returns comparison

Trailing returns across standard periods

Investor sentiment on Pluang

What Pluang investors did over the last 30 days

IONS

100% Buy0% Sell

Avg holding period · 0 Days

VOO

92% Buy8% Sell

Avg holding period · 57 Days

Top news

Latest headlines on both assets

IONS

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VOO

Low-volatility ETF USMV cut worst drop to 8.91% but cost $131K less growth over 5 years vs S&P 500 ETF.24/7 Wall Street · 1 day agoNeutral Schwab's SCHG ETF outperformed SCHD and VOO, turning $90K deposits into nearly $390K over 14 years.24/7 Wall Street · 2 days agoBullish VT ETF offers global diversification with 9,000 stocks, avoiding risks of betting solely on U.S. markets.24/7 Wall Street · 3 days agoBullish View details →

About Ionis Pharmaceuticals Inc. Common Stock

Ionis Pharmaceuticals Inc. is a biopharmaceutical company that develops RNA-targeted medicines using its antisense technology, with marketed treatments in neurology and cardiometabolic disease.

About Vanguard S&P 500 ETF

VOO is a foundational ETF that tracks the S&P 500 Index, providing exposure to 500 of the largest and most established companies in the United States. Renowned for its ultra-low expense ratio and tax efficiency, it serves as a core building block for long-term investors seeking to capture the total return of the U.S. large-cap market in a single, highly liquid vehicle.