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Compare Illumina, Inc. (ILMN) vs Vanguard Total Stock Market Index Fund ETF (VTI) Price & Performance

Illumina, Inc.Trade
Vanguard Total Stock Market Index Fund ETFTrade

Price performance (Past 24H)

Key statistics

Illumina, Inc. vs Vanguard Total Stock Market Index Fund ETF — how do they compare? Illumina, Inc. trades at $272.76 (market cap $39.95B), while Vanguard Total Stock Market Index Fund ETF trades at $381.71 (market cap $2.30T). The key difference: Vanguard Total Stock Market Index Fund ETF is far larger — about 57.6× Illumina, Inc.'s market cap, and Illumina, Inc. is more actively traded (3,169,503 versus 2,982,924). Which is the better fit depends on your goals — on Pluang, investors hold Illumina, Inc. for 83 Days and Vanguard Total Stock Market Index Fund ETF for 131 Days on average.

ILMNVTI
Market Cap
$39.95B$2.30T
Volume
3,169,5032,982,924
Sector
Health—
52-Week High
$293.69$384.30
52-Week Low
$91.00$311.68
Typical Hold Time
83 Days131 Days
Enterprise Value
$41.31B—

Aura AI Summary

Signals from Pluang's Aura AI — not financial advice

Illumina, Inc.

Illumina (ILMN) trades at $271.02, up 1.22% and near its 52-week high, reflecting strong momentum. The stock exhibits a bullish technical trend with recent earnings beats and a positive analyst consensus. Revenue for 2025 was $4.34B with net income of $850M, marking a significant profit margin recovery. Cash flow from operations remains robust at $1.08B, supporting financial stability. Inclusion in the S&P 500 and focus on AI-driven genomics growth are key catalysts.

Outlook is positive given earnings momentum and strategic initiatives, but risks include valuation premiums and competitive pressures. The stock offers growth exposure to genomic innovation, though investors should monitor execution on AI integration and margin sustainability. Analyst price targets suggest moderate upside from current levels, with consensus at $241.00.

Vanguard Total Stock Market Index Fund ETF

VTI trades at $380.52, down slightly by 0.13% with a bullish technical signal from moving averages. The ETF maintains broad U.S. equity exposure across 3,500+ stocks, though concentration in top holdings remains significant. Recent news highlights long-term growth potential with $500 monthly investments since 2001 growing to approximately $876,000 according to Motley Fool (2026-10-01).

VTI offers diversified U.S. market access with low costs, suitable for long-term investors. Risks include market concentration in top holdings and broader economic sensitivity. Analyst sentiment remains positive for buy-and-hold strategies, though recent articles question the value added by small/mid-cap exposure versus S&P 500-focused alternatives.

Returns comparison

Trailing returns across standard periods

Investor sentiment on Pluang

What Pluang investors did over the last 30 days

ILMN
96% Buy4% Sell
Avg holding period · 83 Days
VTI
75% Buy25% Sell
Avg holding period · 131 Days

Top news

Latest headlines on both assets

About Illumina, Inc.

Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (less than 10% of sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.

Read more on ILMN →

About Vanguard Total Stock Market Index Fund ETF

The fund employs an indexing investment approach designed to track the performance of the index, which represents approximately 100% of the investable US stock market and includes large-, mid-, small-, and micro-cap stocks. It invests by sampling the index, meaning that it holds a broadly diversified collection of securities that, in the aggregate, approximates the full index in terms of key characteristics.

Read more on VTI →