Illumina, Inc. vs Vanguard S&P 500 ETF — how do they compare? Illumina, Inc. trades at $189.78 (market cap $27.94B), while Vanguard S&P 500 ETF trades at $687.92. Which is the better fit depends on your goals.
| ILMN | VOO | |
|---|---|---|
Market Cap | $27.94B | — |
Sector | Health | Broad Market / Factor |
52-Week High | $194.33 | $698.29 |
52-Week Low | $91.00 | $571.45 |
Enterprise Value | $29.33B | — |
Signals from Pluang's Aura AI — not financial advice
Illumina (ILMN) trades at $185.36, down 0.69% on the day, with a bullish technical signal from moving averages. The stock shows strong profitability with a 19.42% net income margin and has beaten EPS estimates for three consecutive quarters. Recent news highlights expansion of the Billion Cell Atlas program and upcoming Q2 2026 earnings on July 30.
Outlook remains positive with 51% analyst buy ratings, though the current price exceeds the $178 consensus target. Key risks include competitive pressure from Roche's new sequencer and China market weakness. Earnings growth and cost control initiatives support upside potential, but valuation multiples suggest limited near-term appreciation.
VOO trades at $682.20, down 0.14% with a bearish technical signal from moving averages. The ETF shows neutral momentum indicators with RSI at 51.60, while support levels cluster around $677-681. Recent news highlights S&P 500 concentration risks and ongoing debates about market valuation levels amid tech dominance.
The outlook remains cautious as technical weakness contrasts with long-term ETF benefits. Key risks include market concentration in tech stocks and potential valuation concerns, while the dividend yield provides income support for patient investors seeking broad market exposure.
Trailing returns across standard periods
Latest headlines on both assets
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (less than 10% of sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
Read more on ILMN →VOO is a foundational ETF that tracks the S&P 500 Index, providing exposure to 500 of the largest and most established companies in the United States. Renowned for its ultra-low expense ratio and tax efficiency, it serves as a core building block for long-term investors seeking to capture the total return of the U.S. large-cap market in a single, highly liquid vehicle.
Read more on VOO →