Illumina, Inc. vs S&P Global Inc — how do they compare? Illumina, Inc. trades at $189.49 (market cap $27.94B), while S&P Global Inc trades at $432.81 (market cap $132.71B). The key difference: S&P Global Inc is far larger — about 4.7× Illumina, Inc.'s market cap, and S&P Global Inc pays a 0.87% dividend while Illumina, Inc. pays none. Which is the better fit depends on your goals.
| ILMN | SPGI | |
|---|---|---|
Market Cap | $27.94B | $132.71B |
Sector | Health | Financials |
52-Week High | $194.33 | $534.79 |
52-Week Low | $91.00 | $370.42 |
Enterprise Value | $29.33B | $144.68B |
Dividend Yield | — | 0.87% |
Signals from Pluang's Aura AI — not financial advice
Illumina (ILMN) trades at $185.36, down 0.69% on the day, with a bullish technical signal from moving averages. The stock shows strong profitability with a 19.42% net income margin and has beaten EPS estimates for three consecutive quarters. Recent news highlights expansion of the Billion Cell Atlas program and upcoming Q2 2026 earnings on July 30.
Outlook remains positive with 51% analyst buy ratings, though the current price exceeds the $178 consensus target. Key risks include competitive pressure from Roche's new sequencer and China market weakness. Earnings growth and cost control initiatives support upside potential, but valuation multiples suggest limited near-term appreciation.
S&P Global (SPGI) trades at $449.75, down 0.24% on the day, with a bullish technical outlook and strong fundamentals. The stock shows robust profitability with a 30.36% net income margin and consistent revenue growth, reaching $15.34B in 2025. Recent corporate actions include the spinoff of Mobility Global, streamlining operations. Analyst consensus is strongly bullish with a $531.11 price target, and technical indicators signal a buy from moving averages despite overbought RSI levels.
The outlook for SPGI is positive, driven by margin expansion targets, AI-driven growth in API usage, and resilient recurring revenues. Key risks include high valuation multiples and sensitivity to debt issuance cycles. Investment opportunity lies in its market-leading position and strategic focus post-spinoff, though investors should monitor execution on growth initiatives and macroeconomic factors affecting capital markets.
Trailing returns across standard periods
Latest headlines on both assets
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (less than 10% of sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
Read more on ILMN →S&P Global provides data and benchmarks to capital and commodity market participants. In 2021 and excluding IHS Markit, S&P Ratings was over 45% of the firm's revenue and over 55% of the firm's operating income. S&P Ratings is the largest credit rating agency in the world. The firm's other segments include Market Intelligence, Indices, and Platts. Market Intelligence provides desktop tools and other data solutions to investment banks, corporations, and other entities. Indices provides benchmarks for financial markets and is monetized through subscriptions, asset-based fees, and transaction-based royalties. Platts provides benchmarks to commodity markets, principally petroleum.
Read more on SPGI →