Illumina, Inc. vs Super Micro Computer Inc — how do they compare? Illumina, Inc. trades at $180.13 (market cap $27.94B), while Super Micro Computer Inc trades at $24.49 (market cap $15.41B). The key difference: Illumina, Inc. is the larger of the two by market cap, and Illumina, Inc. is trading nearer its 52-week high, Super Micro Computer Inc nearer its low. Which is the better fit depends on your goals.
| ILMN | SMCI | |
|---|---|---|
Market Cap | $27.94B | $15.41B |
Sector | Health | Technology |
52-Week High | $194.33 | $60.71 |
52-Week Low | $91.00 | $20.53 |
Enterprise Value | $29.33B | $22.93B |
Signals from Pluang's Aura AI — not financial advice
Illumina (ILMN) trades at $185.36, down 0.69% on the day, with a bullish technical signal from moving averages. The stock shows strong profitability with a 19.42% net income margin and has beaten EPS estimates for three consecutive quarters. Recent news highlights expansion of the Billion Cell Atlas program and upcoming Q2 2026 earnings on July 30.
Outlook remains positive with 51% analyst buy ratings, though the current price exceeds the $178 consensus target. Key risks include competitive pressure from Roche's new sequencer and China market weakness. Earnings growth and cost control initiatives support upside potential, but valuation multiples suggest limited near-term appreciation.
Super Micro Computer (SMCI) trades at $23.83, down 1.41% on the day, with a bearish technical signal despite recent earnings beats. Valuation ratios appear attractive with a P/E of 12.73 and P/S of 0.48, but cash flow trends show strain with a projected negative net cash flow of $1.2B in 2026. The company is expanding its liquid cooling portfolio for AI data centers, but faces investor concerns over inventory growth and competitive pressures.
The outlook is mixed: strong AI demand and low valuations offer upside potential, but cash flow volatility, rising competition, and a Taiwan regulatory probe pose significant risks. Analyst consensus is cautious with a $36.71 price target, reflecting 54% upside, yet hold ratings dominate at 56% due to near-term execution challenges.
Trailing returns across standard periods
Latest headlines on both assets
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (less than 10% of sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
Read more on ILMN →Super Micro Computer, Inc., commonly known as Supermicro, is a leading provider of high-performance and high-efficiency server technology and innovation. The company specializes in designing, manufacturing, and selling advanced server, storage, and networking solutions, primarily for data centers, cloud computing, artificial intelligence, and 5G/Edge computing markets. SMCI's modular architecture allows for the rapid delivery of customized and purpose-built solutions, making it a key player in the enterprise computing and specialized AI infrastructure space.
Read more on SMCI →