Illumina, Inc. vs Merck & Co., Inc. — how do they compare? Illumina, Inc. trades at $193.06 (market cap $29.12B), while Merck & Co., Inc. trades at $130.22 (market cap $321.77B). The key difference: Merck & Co., Inc. is far larger — about 11× Illumina, Inc.'s market cap, and Merck & Co., Inc. pays a 2.61% dividend while Illumina, Inc. pays none. Which is the better fit depends on your goals.
| ILMN | MRK | |
|---|---|---|
Market Cap | $29.12B | $321.77B |
Sector | Health | Health |
52-Week High | $205.10 | $131.84 |
52-Week Low | $91.00 | $77.60 |
Enterprise Value | $30.48B | $368.53B |
Dividend Yield | — | 2.61% |
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Merck (MRK) trades at $130.90, up 1.81% on the day, with a bullish technical outlook and strong institutional support. Recent earnings beats in Q4 2025 and Q1-Q2 2026, alongside a 28.07% net income margin in 2025, highlight operational strength. The acquisition of Terns Pharmaceuticals aims to bolster its oncology pipeline, though a high P/E of 104.74 signals premium valuation. Cash flow remains positive at $1.37B in 2025, but investing outflows have increased.
The stock offers growth potential from pipeline expansion and analyst consensus targeting $140.36, but risks include elevated debt-to-asset ratios (36.06% in 2025) and competitive pressures. Investors should weigh robust profitability against valuation concerns and macroeconomic headwinds affecting the pharma sector.
Trailing returns across standard periods
Latest headlines on both assets
Illumina provides tools and services to analyze genetic material with life science and clinical lab applications. The company generates over 90% of its revenue from sequencing instruments, consumables, and services. Illumina's high-throughput technology enables whole genome sequencing in humans and other large organisms. Its lower throughput tools enable applications that require smaller data outputs, such as viral and cancer tumor screening. Illumina also sells microarrays (less than 10% of sales) that enable lower-cost, focused genetic screening with primarily consumer and agricultural applications.
Read more on ILMN →Merck makes pharmaceutical products to treat several conditions in a number of therapeutic areas, including cardiometabolic disease, cancer, and infections. Within cancer, the firm's immuno-oncology platform is growing as a major contributor to overall sales. The company also has a substantial vaccine business, with treatments to prevent hepatitis B and pediatric diseases as well as HPV and shingles. Additionally, Merck sells animal health-related drugs. From a geographical perspective, just under half of the firm's sales are generated in the United States.
Read more on MRK →