Ginkgo Bioworks Holdings Inc vs Upwork Inc — how do they compare? Ginkgo Bioworks Holdings Inc trades at $7.29 (market cap $505.73M), while Upwork Inc trades at $8.33 (market cap $1.04B). The key difference: Upwork Inc is far larger — about 2.1× Ginkgo Bioworks Holdings Inc's market cap, and Ginkgo Bioworks Holdings Inc is trading nearer its 52-week high, Upwork Inc nearer its low. Which is the better fit depends on your goals.
| DNA | UPWK | |
|---|---|---|
Market Cap | $505.73M | $1.04B |
Sector | Health | Industrials |
52-Week High | $16.14 | $22.11 |
52-Week Low | $5.48 | $7.84 |
Enterprise Value | $607.68M | $806.15M |
Signals from Pluang's Aura AI — not financial advice
Ginkgo Bioworks (DNA) trades at $7.42, down 3.01% with bearish technical signals. The company reported Q2 2026 revenue of $20M, down 48% year-over-year, while maintaining a high gross margin of 68.04% but significant net losses. Analyst sentiment is mixed with 45% buy ratings amid ongoing business model transition to autonomous laboratory systems and contract research services.
The outlook remains challenging with persistent revenue declines and negative cash flow, though recent earnings beats provide some optimism. Key risks include execution of the business pivot and path to profitability. Wall Street shows cautious optimism with majority buy ratings despite fundamental headwinds.
UPWK is trading at $8.25, down 16.12% amid weak guidance overshadowing a recent Q2 earnings beat. The stock shows bearish technical signals with key support at $8.00. Fundamentally, revenue grew to $787.78M in 2025 with a net income margin of 12.93%, though earnings have been mixed with three misses in the last four quarters. Recent news highlights concerns over declining active clients and AI-driven market shifts.
The outlook is cautious; while valuation ratios like P/E of 10.71 appear reasonable, near-term risks from competitive pressures and investor lawsuits pose headwinds. Analyst consensus is a Buy with a $9.25 target, suggesting potential upside if execution improves, but sentiment remains fragile post-earnings.
Trailing returns across standard periods
Latest headlines on both assets
Ginkgo Bioworks is a leading horizontal platform for cell programming. It uses advanced automation and software to design custom organisms for customers across diverse industries, including food, agriculture, and pharma.
Read more on DNA →Upwork Inc is a United States-based company that operates an online marketplace that enables businesses to find and work with highly-skilled independent professionals. The develops platform for hiring and freelancing purposes. Its products offering include Upwork Basic, Upwork Plus, Upwork Business, Upwork Enterprise, and Upwork Payroll. The business generates revenue from Talent and Clients across the USA, India, the Philippines and the rest of the world. Substantial income is derived from providing services to Clients.
Read more on UPWK →