Crispr Therapeutics AG vs Nomura Holdings Inc — how do they compare? Crispr Therapeutics AG trades at $51.49 (market cap $4.97B), while Nomura Holdings Inc trades at $10.05 (market cap $28.06B). The key difference: Nomura Holdings Inc is far larger — about 5.6× Crispr Therapeutics AG's market cap, and Nomura Holdings Inc pays a 3.32% dividend while Crispr Therapeutics AG pays none. Which is the better fit depends on your goals.
| CRSP | NMR | |
|---|---|---|
Market Cap | $4.97B | $28.06B |
Sector | Health | Financials |
52-Week High | $76.78 | $9.75 |
52-Week Low | $44.34 | $6.30 |
Enterprise Value | $3.32B | — |
Dividend Yield | — | 3.32% |
Signals from Pluang's Aura AI — not financial advice
CRSP trades at $50.63, down 5.1% over 24 hours, amid a bearish technical signal. The company shows deep losses with a net income margin of -56,853.4% in 2025 and negative cash flow from operations. However, analyst consensus remains optimistic with a $74.50 price target, and recent news highlights FDA approval for Casgevy, expanding its gene therapy market.
The outlook hinges on commercial execution of Casgevy and pipeline progress, offering high growth potential in gene editing. Key risks include sustained cash burn, competitive pressures, and regulatory hurdles. Despite current financial challenges, strong analyst buy ratings suggest confidence in long-term value.
Nomura Holdings (NMR) trades at $9.62, down 0.41% on the day, with a P/E of 13.08 suggesting reasonable valuation. The stock shows bullish technical signals with strong moving average support, though RSI levels indicate overbought conditions. Recent earnings show mixed results with one beat and two misses, but annual revenue grew to $1.66 trillion with a robust 20.49% net margin. The company posted record annual profit of $340.74 billion in 2025, driving positive sentiment around its wholesale and wealth management segments.
Nomura presents a compelling value opportunity with strong profitability metrics and expansion in core businesses, though recent earnings misses and negative operating cash flow pose near-term concerns. The bullish analyst consensus and technical setup support upside potential, but investors should monitor integration costs from recent acquisitions and debt levels that have increased to 26.25% of assets.
Trailing returns across standard periods
CRISPR Therapeutics is a gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. The company is focused on using this technology to treat genetically defined diseases. CRISPR's most advanced pipeline candidate, CTX001, is in collaboration with Vertex Pharmaceuticals and targets sickle cell disease and transfusion-dependent beta-thalassemia, which have high unmet medical needs. The company is progressing additional gene editing programs for immuno-oncology, as well as a stem cell-derived therapy for the treatment of Type 1 diabetes.
Read more on CRSP →Nomura is Japan's largest broker, about twice the size of rival Daiwa Securities and roughly three times the size of the securities units of the three megabanks. It is also the largest asset-management company in Japan, with a similar size differential compared with its rivals. Despite its topnotch brand name in retail broking and asset management in Japan, Nomura has struggled to compete effectively in the institutional securities business against larger global rivals. In 2008, Nomura bought European and Asian assets of the failed Lehman Brothers, which led to a sharply higher cost base but did not provide commensurate revenue. Nomura has reduced the scale of these businesses but maintains its ambition to compete globally with the top players.
Read more on NMR →