Compare Alnylam Pharmaceuticals, Inc. (ALNY) vs Home Depot Inc (HD) Price & Performance
Price performance (Past 24H)
Key statistics
Key statistics
Alnylam Pharmaceuticals, Inc. vs Home Depot Inc — how do they compare? Alnylam Pharmaceuticals, Inc. trades at $220.35 (market cap $29.60B), while Home Depot Inc trades at $354.65 (market cap $353.46B). The key difference: Home Depot Inc is far larger — about 11.9× Alnylam Pharmaceuticals, Inc.'s market cap, and Home Depot Inc pays a 2.63% dividend while Alnylam Pharmaceuticals, Inc. pays none. Which is the better fit depends on your goals.
| ALNY | HD | |
|---|---|---|
Market Cap | $29.60B | $353.46B |
Sector | Health | Consumer Cyclical |
52-Week High | $491.22 | $423.42 |
52-Week Low | $205.48 | $297.51 |
Enterprise Value | $27.56B | $415.01B |
Dividend Yield | — | 2.63% |
Aura AI Summary
Signals from Pluang's Aura AI — not financial advice
Aura AI Summary
Signals from Pluang's Aura AI — not financial advice
No Aura AI signal available yet.
Home Depot (HD) trades at $350.78, down 1.36% on the day, with a bullish technical outlook supported by moving averages. The company reported mixed quarterly earnings, missing in Q3 2025 but beating in Q4 2025 and Q1 2026. Strong profitability metrics include a 33.13% gross margin and 128.38% ROE, though net margins have declined from 10.87% in 2022 to 8.41% in 2026. Recent news highlights institutional trading activity and concerns about weakening big-ticket demand amid rising mortgage rates.
The stock offers a 6% upside to the consensus price target of $371.25, with 59% of analysts rating it Buy. Key risks include housing market sensitivity and margin pressure from investments. Long-term growth drivers include Pro customer focus and digital expansion, but near-term headwinds from economic conditions warrant caution.
Returns comparison
Trailing returns across standard periods
Returns comparison
Trailing returns across standard periods
About Alnylam Pharmaceuticals, Inc.
Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam has five drugs on the market: Onpattro and Amvuttra for hATTR amyloidosis, Givlaari for acute hepatic porphyria, Oxlumo for primary hyperoxaluria type 1, and Leqvio for hypercholesterolemia.
Read more on ALNY →About Home Depot Inc
Home Depot is the world's largest home improvement specialty retailer, operating more than 2,300 warehouse-format stores offering more than 30,000 products in store and 1 million products online in the United States, Canada, and Mexico. Its stores offer numerous building materials, home improvement products, lawn and garden products, and decor products and provide various services, including home improvement installation services and tool and equipment rentals. The acquisition of distributor Interline Brands in 2015 allowed Home Depot to enter the maintenance, repair, and operations business, which has been expanded through the tie-up with HD Supply (2020). The addition of the Company Store brought textile exposure to Home Depot's lineup.
Read more on HD →
