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Wave Life Sciences starts Phase 2a trial of WVE-007 for obesity, showing promising fat loss and muscle preservation.

Company Fundamentals
24 Jun 2026
GlobeNewsWire
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Bullish
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Wave Life Sciences has initiated the Phase 2a portion of its INLIGHT™ trial to test WVE-007, an investigational RNA medicine targeting obesity and related cardiometabolic diseases. Earlier Phase 1 results showed that a single dose of WVE-007 significantly reduced visceral fat by 14% and total fat by 5% while preserving muscle, with potential for once or twice-yearly dosing. The Phase 2a trial will enroll individuals with higher BMI and include assessments of body composition, weight loss, and metabolic health markers over 12 months. This trial aims to further validate WVE-007's potential to improve obesity treatment and reduce risks for type 2 diabetes and cardiovascular disease, with additional Phase 2 trials planned for later in 2026.

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