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Palisade Bio advances gut-restricted PDE4 inhibitor PALI-2108 with promising Phase 1 results and funding through 2028.

Market News
10 Jul 2026
Seeking Alpha
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Bullish
pluang ai news

Palisade Bio is developing PALI-2108, a gut-restricted PDE4 inhibitor targeting ulcerative colitis and Crohn’s disease. Phase 1 trials showed favorable safety, target engagement, and early clinical activity, indicating a potentially differentiated mechanism. With $132.6 million in cash, the company is funded through key Phase 2 efficacy results expected in 2027–2028, minimizing near-term dilution risk. If PALI-2108’s efficacy is confirmed in larger trials, it could achieve significant market value similar to other oral ulcerative colitis therapies that have reached multi-billion dollar acquisitions.

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