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Candel Therapeutics launches global Phase 3 trial for lung cancer drug aglatimagene besadenovec.

Company Fundamentals
30 Jun 2026
Globe News Wire
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Candel Therapeutics has initiated the global pivotal Phase 3 AURORA trial to evaluate aglatimagene besadenovec (CAN-2409) combined with valacyclovir and pembrolizumab in patients with advanced non-squamous non-small cell lung cancer (NSCLC) who have not responded adequately to prior immune checkpoint inhibitors and chemotherapy. The trial will compare this treatment against standard docetaxel chemotherapy, enrolling patients worldwide across 150 sites with overall survival as the primary endpoint. This trial builds on promising Phase 2 results showing extended survival, addressing a critical unmet need for patients with limited options after progression on current therapies. The FDA has granted Fast Track Designation to aglatimagene for NSCLC, highlighting its potential as a novel immunotherapy.

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The global autoimmune disease therapeutics market is projected to grow from $80.54 billion in 2025 to $137.85 billion by 2035, at a CAGR of 5.52%. Growth is fueled by rising autoimmune disease prevalence, advances in biologics, JAK inhibitors, monocl...

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Health plan cuts machine-readable file production from 45 days to under 24 hours with TALON integration

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