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Access barriers limit Xphozah uptake despite nephrologists' willingness to triple use, with reimbursement changes ahead.

Market News
29 Jul 2026
Spherix Global Insights
View Source
Neutral
Access barriers limit Xphozah uptake despite nephrologists' willingness to triple use, with reimbursement changes ahead.

New research from Spherix Global Insights reveals that access barriers, not drug efficacy, restrict the use of Ardelyx's Xphozah for dialysis patients with hyperphosphatemia. Nephrologists say they would nearly triple Xphozah prescriptions if reimbursement and coverage obstacles were removed. However, physicians also overestimate how well phosphorus levels are controlled and how often combination therapies are used. As the Transitional Drug Add-on Payment Adjustment (TDAPA) ends in 2026, reimbursement changes may further impact phosphate-lowering therapy markets. The study highlights a gap between treatment potential and real-world use, with dietitians playing a key role in therapy decisions and gastrointestinal side effects affecting patient persistence on Xphozah.

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