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Amgen downgraded after Novartis trial failure raises doubts on cholesterol drug prospects

Market News
08 Sep 2026
Stuart Mooney
View Source
Bearish
Amgen downgraded after Novartis trial failure raises doubts on cholesterol drug prospects

Investment firm BMO Capital downgraded Amgen's stock from "Outperform" to "Market Perform" following a major clinical trial failure by Novartis for a similar cholesterol drug. Novartis' drug pelacarsen failed in a late-stage Phase III trial, casting uncertainty on Amgen's olpasiran, which targets the same high Lp(a) cholesterol market. Amgen shares dropped 5% after the news but have still gained 36.3% year-to-date, outperforming the industry. The downgrade signals cautious investor sentiment amid increased risks for this multi-billion dollar drug market segment.

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