Alnylam Pharmaceuticals, Inc. vs S&P500 ETF — how do they compare? Alnylam Pharmaceuticals, Inc. trades at $221.2 (market cap $29.60B), while S&P500 ETF trades at $772.3. The key difference: S&P500 ETF is trading nearer its 52-week high, Alnylam Pharmaceuticals, Inc. nearer its low. Which is the better fit depends on your goals.
| ALNY | SPY | |
|---|---|---|
Market Cap | $29.60B | — |
Sector | Health | — |
52-Week High | $491.22 | $773.22 |
52-Week Low | $205.48 | $631.99 |
Enterprise Value | $27.56B | — |
Signals from Pluang's Aura AI — not financial advice
ALNY trades at $223.43, up 2.97% in 24 hours, with a bearish technical signal despite recent gains. The stock shows strong profitability with a 79.65% gross margin and 96.55% ROE, but valuation ratios like P/E of 38.54 are elevated. Recent Q2 2026 earnings missed estimates, and multiple law firms are investigating potential securities fraud, adding uncertainty.
Outlook is mixed: analyst consensus is bullish with a $370.07 price target, but risks include ongoing fraud probes and earnings volatility. Revenue growth is robust, projected to reach $4.8B in 2026, yet investors face headwinds from legal issues and technical bearishness.
SPY, the SPDR S&P 500 ETF Trust, trades at $772.47, down 0.08% on the day, with a bullish technical signal from moving averages but overbought RSI readings. The ETF's valuation metrics are not applicable as it tracks the S&P 500 index, and it announced a $1.90 dividend payable in July 2026. Recent news highlights the S&P 500 reaching record highs amid mixed sentiment, with some analysts cautioning on high valuations while others project further gains.
The outlook for SPY is cautiously optimistic, driven by strong market momentum and corporate earnings, but faces risks from elevated valuations and potential inflation pressures. Investment opportunity lies in broad U.S. equity exposure, while key risks include market volatility and economic data surprises.
Trailing returns across standard periods
Latest headlines on both assets
Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam has five drugs on the market: Onpattro and Amvuttra for hATTR amyloidosis, Givlaari for acute hepatic porphyria, Oxlumo for primary hyperoxaluria type 1, and Leqvio for hypercholesterolemia.
Read more on ALNY →The ETF is designed to track the performance of the securities and the stocks in the S&P 500 Index. To maintain the composition and weightings, the advisor adjusts the ETF from time to time to conform to periodic changes in the index target.
Read more on SPY →