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Soligenix halts Phase 3 trial of HyBryte for cutaneous T-cell lymphoma due to futility at interim analysis

Company Fundamentals
28 Apr 2026
PRNewsWire
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Bearish
pluang ai news

Soligenix announced that its Phase 3 FLASH 2 trial for HyBryte, a treatment for cutaneous T-cell lymphoma (CTCL), was stopped early after an interim analysis showed the study was unlikely to meet its efficacy goals. This outcome is disappointing as the first Phase 3 trial showed significant lesion reduction, but the second trial did not replicate these results over 18 weeks. The company will analyze the data further to identify any patient subsets that might benefit and consider next steps including discussions with regulators and exploring other pipeline assets like dusquetide for Behçet's Disease. With $5.9 million in cash, Soligenix is also open to strategic options such as mergers or acquisitions.

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