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Silence Therapeutics rated speculative Buy on promising polycythemia vera drug with key Phase 2 data due 2026

Analyst Insights
12 Jul 2026
Seeking Alpha
View Source
Bullish
pluang ai news

Willow Tree Research initiates coverage of Silence Therapeutics with a speculative Buy rating, driven by the potential of its mRNAi drug divesiran (SLN124) for treating polycythemia vera (PV). The drug's platform allows infrequent dosing and strong target knockdown, which may differentiate it from competitors. Early Phase 1 data showed promising reductions in phlebotomy and symptom improvements, but confirmation of safety and efficacy is awaited in a pivotal Phase 2 readout expected in August 2026. Despite high clinical and financial risks, the company's discounted valuation and additional drug development opportunities create an attractive risk-reward profile ahead of this key catalyst.

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