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Sanofi's Nuvaxovid COVID-19 vaccine shows better tolerance than Moderna's mNEXSPIKE in a major study.

Market News
18 Apr 2026
Sanofi
View Source
Bullish
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A phase 4 randomized double-blind study comparing Sanofi's protein-based COVID-19 vaccine Nuvaxovid with Moderna's mRNA vaccine mNEXSPIKE found Nuvaxovid to have significantly fewer and milder side effects. The study of 1,000 US adults showed systemic side effects that disrupt daily activities were over 50% less frequent with Nuvaxovid. Local injection site reactions were also much lower. These findings could improve vaccine acceptance and yearly booster uptake as concerns about side effects remain a major barrier to COVID-19 vaccination. Sanofi plans to expand Nuvaxovid availability globally in 2026.

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