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Retatrutide hits 28.7% weight loss, matching surgery results, but competition and IP battles intensify.

Market News
29 Apr 2026
Patentvest
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Eli Lilly's retatrutide achieved a 28.7% average weight loss in April 2026, marking the first non-surgical treatment to rival bariatric surgery outcomes. This breakthrough shifts the focus from drug development to intellectual property control and market access, as companies like Novo Nordisk, Pfizer, Hanmi, and Sanofi compete with various triple-agonist therapies. The challenge now lies in bridging the gap between clinical trial results and real-world effectiveness, termed "The Last 20%". PatentVest's report highlights the evolving pipeline, deal-making, and IP strategies that will determine which players dominate the surgery-level weight loss market without surgery.

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