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FDA approves ICOTYDE for plaque psoriasis, triggering $50M milestone for Protagonist Therapeutics

Market News
23 Mar 2026
Defense World
View Source
Bullish
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Protagonist Therapeutics announced FDA approval of ICOTYDE for moderate-to-severe plaque psoriasis in adults and adolescents, marking a major milestone with a $50 million payment. The oral peptide therapy targets the IL-23 receptor, offering a novel alternative to injectable treatments. Supported by extensive Phase 3 trials, the drug shows strong efficacy and safety, with Johnson & Johnson managing commercialization. Protagonist is exploring ICOTYDE's potential in other immune diseases and expects further milestones and royalties from its collaboration with Johnson & Johnson. Additional pipeline updates include an FDA decision expected for rusfertide in Q3 and ongoing development of oral therapies for immune and metabolic diseases.

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