More than 25 pharmaceutical companies are actively developing over 30 PARP inhibitor drugs, targeting cancers like breast, prostate, and solid tumors. These drugs work by blocking DNA repair in cancer cells, leading to cell death, especially in tumors with BRCA mutations. Key players include AstraZeneca, Gilead Sciences, and others, with several drugs in various trial phases from preclinical to Phase III. The growing focus on precision medicine and combination therapies is driving adoption, despite challenges like high costs and resistance.
Deutsche Bank maintains a sell rating on AstraZeneca with a price target of 11,500p, despite shares trading at 13,064p. The bank views the recent ASCO conference data, including the positive phase III EMERALD-3 trial for liver cancer, as incremental ...
Deutsche Bank maintained its sell rating and 11,500p price target on AstraZeneca shares despite positive phase III trial results presented at the ASCO 2026 conference. The EMERALD-3 trial showed a 30% reduction in disease progression risk for a liver...
AstraZeneca reported updated Phase 3 SERENA-6 trial results showing that camizestrant combined with a CDK4/6 inhibitor significantly improved progression-free survival in hormone receptor-positive, HER2-negative advanced breast cancer. The treatment ...
AstraZeneca's Phase 3 EMERALD-3 trial demonstrated that the STRIDE regimen, combining immunotherapy drugs Imfinzi and Imjudo with lenvatinib and TACE, significantly improved progression-free survival by 30% compared to TACE alone in patients with unr...
At ASCO 2026, European pharma firms had a quiet showing, but AstraZeneca and Roche faced key challenges. AstraZeneca's lung cancer drug Datroway competes with Merck's sac-TMT, which showed strong efficacy but high toxicity, making AstraZeneca's bioma...
