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Sionna shares plunge 92% after Phase 2a trial of SION-719 fails key sweat chloride endpoint

Market News
19 Aug 2026
PRNewsWire
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Bearish
pluang ai news

Sionna Therapeutics' shares dropped about 92% following the failure of its Phase 2a PreciSION CF trial for SION-719, which did not meet the key sweat chloride reduction endpoint. The company announced it will not advance SION-719 as an add-on therapy despite having strong cash reserves of $268.3 million as of June 2026. This setback impacts Sionna's cystic fibrosis pipeline, which heavily depends on its NBD1 stabilizer programs. Investors who suffered losses are being encouraged to seek legal review for potential recovery options.

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