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Fulcrum Therapeutics shares plunge 50% after FDA halts pociredir program over safety concerns.

Market News
02 Jun 2026
PRNewsWire
View Source
Bearish
pluang ai news

Fulcrum Therapeutics saw its stock drop about 50% after the FDA raised safety concerns that forced the immediate discontinuation of its drug pociredir and triggered a strategic review. The company had previously projected a Phase III trial timeline and competitive lead, but FDA feedback eliminated the regulatory path forward. Despite ending the program, Fulcrum remains locked into a $25.1 million lease and a licensing deal with up to $70 million in milestone payments. The company now faces uncertainty without a lead clinical candidate, and a securities law investigation is underway regarding potential misleading statements about the drug's outlook and financial commitments.

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