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MetaVia's DA-1726 shows 9.1% weight loss at Day 54; vanoglipel combos boost liver and metabolic health in preclinical tests

Market News
08 Jun 2026
PRNewsWire
View Source
Bullish
pluang ai news

MetaVia Inc. announced promising Phase 1 results for DA-1726, a dual GLP1R/GCGR agonist, showing up to 9.1% mean body weight reduction by Day 54 without plateau, alongside reduced waist circumference and BMI. Preclinical studies revealed that vanoglipel combined with resmetirom or metformin produced synergistic benefits in liver health, glycemic control, and weight loss in models of metabolic diseases. These findings support DA-1726 as a differentiated obesity therapy and vanoglipel as a versatile candidate for combination treatments in metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes. MetaVia plans to continue higher-dose evaluations with results expected by Q4 2026.

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