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Maze Therapeutics reports positive Phase 2 data for kidney disease drug MZE829, plans pivotal trial.

Company Fundamentals
25 Mar 2026
GlobeNewsWire
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Bullish
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Maze Therapeutics announced positive topline results from its Phase 2 HORIZON trial of MZE829, showing a significant reduction in proteinuria in patients with APOL1-mediated kidney disease (AMKD). The drug demonstrated a 35.6% mean reduction in urinary albumin-to-creatinine ratio at week 12, with no serious adverse events reported. Maze plans to advance MZE829 into a pivotal program and start two Phase 2 trials for MZE782 targeting phenylketonuria and chronic kidney disease in 2026. The company also strengthened its board with Neil Kumar, CEO of BridgeBio, and reported a strong cash position of $360 million, supporting operations into 2028.

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