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Eli Lilly's new type II JAK2 inhibitor shows promising results in treating myelofibrosis patients resistant to current therapies

Market News
13 Jun 2026
PRNewsWire
View Source
Bullish
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Eli Lilly announced positive Phase 1 results for AJ1-11095, a novel type II JAK2 inhibitor targeting myelofibrosis patients who failed type I JAK2 inhibitors. The drug demonstrated a strong safety profile, significant spleen size reduction, symptom improvement, and mutation burden decrease in a trial of 23 patients. These findings suggest a new treatment option for patients with limited alternatives. Lilly plans to advance clinical development and explore broader applications in related blood disorders.

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