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Phase 3 study shows pirtobrutinib plus venetoclax improves outcomes in relapsed CLL patients

Market News
02 Jun 2026
PRNewsWire
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Bullish
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Eli Lilly announced positive Phase 3 BRUIN CLL-322 study results showing that adding pirtobrutinib to venetoclax and rituximab significantly improves progression-free survival in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). This is the first Phase 3 trial in CLL to outperform a venetoclax-based regimen. Lilly will also present early clinical data from Ajax Therapeutics and Kelonia Therapeutics, companies it plans to acquire, highlighting new treatments for myelofibrosis and multiple myeloma. These developments strengthen Lilly's hematology portfolio and offer hope for better blood cancer therapies.

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