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Safety committee approves higher 10 mg/kg dose for Entrada's Duchenne muscular dystrophy trial

Company Fundamentals
02 Jun 2026
Entrada Therapeutics, Inc.
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Bullish
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Entrada Therapeutics announced that an independent Data Monitoring Committee has recommended increasing the dose to 10 mg/kg for Cohort 2 in its ELEVATE-45-201 Phase 1/2 trial for Duchenne muscular dystrophy. This follows safety and pharmacokinetic reviews of Cohort 1 participants dosed at 5 mg/kg. The trial evaluates ENTR-601-45, targeting patients amenable to exon 45 skipping, with dosing every six weeks. Entrada plans to report Cohort 1 data mid-2026, with subsequent data from higher doses to follow, aiming to improve patient outcomes and reduce treatment burden.

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