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Kodiak Sciences starts Phase 3 trial for KSI-501 to treat diabetic macular edema, aiming to outperform aflibercept.

Market News
10 Aug 2026
PRNewsWire
View Source
Bullish
pluang ai news

Kodiak Sciences has begun enrolling patients in the global Phase 3 ALTO trial to test KSI-501, a bispecific therapy targeting both IL-6 inflammation and VEGF pathways, in diabetic macular edema (DME) patients. The trial aims to show KSI-501's superiority over aflibercept, a current standard treatment, by potentially offering better vision improvement and longer-lasting effects with fewer injections. This study follows promising Phase 2 results suggesting dual inhibition could provide enhanced benefits. Results from this trial could lead to a new, more effective treatment option for DME, a condition causing vision loss due to retinal swelling.

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