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Jazz Pharmaceuticals' Phase 3 trial of Zepzelca in relapsed small cell lung cancer misses survival goal

Company Fundamentals
12 Jun 2026
PRNewsWire
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Neutral
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Jazz Pharmaceuticals announced that the Phase 3 LAGOON trial of Zepzelca (lurbinectedin) for second-line treatment of relapsed metastatic small cell lung cancer (SCLC) did not meet its primary endpoint of overall survival. The trial compared Zepzelca alone or with irinotecan against standard treatments but showed no significant survival benefit. However, no new safety concerns emerged, and the drug remains approved for first-line maintenance treatment based on earlier positive results. Jazz will discuss next steps with the FDA regarding post-marketing requirements for the second-line use, and the trial outcome does not affect the company's 2026 financial guidance.

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