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Immatics reports promising Phase 1 data for IMA401 bispecific in solid tumors, advancing lung cancer combo trial.

Market News
31 May 2026
GlobeNewsWire
View Source
Bullish
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Immatics presented Phase 1 clinical trial data for its IMA401 TCR bispecific targeting MAGEA4/8, showing durable responses and good tolerability in heavily pretreated solid tumor patients, including melanoma and head and neck cancer. The data, also published in Nature Medicine, support combining IMA401 with IMA402 (targeting PRAME) to enhance treatment for squamous cell non-small cell lung cancer (sqNSCLC), where over 90% of patients express one or both targets. Enrollment for the combination trial is underway with initial results expected in 2027, marking a significant step in developing off-the-shelf immunotherapies for solid tumors.

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