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New therapy GDNF shows promise in treating fatty liver disease by reprogramming liver fat metabolism.

Market News
13 Apr 2026
PRNewsWire
View Source
Bullish
pluang ai news

Hoth Therapeutics announced positive preclinical results for its therapy GDNF, which reprograms liver fat metabolism at the genetic level to treat metabolic-associated fatty liver disease (MAFLD) and obesity. The therapy significantly reduces Srebf1, a gene driving fat production, and increases Pparα, which regulates fat burning, outperforming existing treatments like semaglutide. Unlike current therapies focused mainly on weight loss, GDNF targets the root causes of fat accumulation in the liver, potentially offering a disease-modifying treatment. Hoth plans further preclinical studies and clinical development to advance this novel metabolic therapy.

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