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Pirtobrutinib combo improves progression-free survival in relapsed CLL patients, per Phase 3 BRUIN CLL-322 trial

Company Fundamentals
13 Apr 2026
PRNewsWire
View Source
Bullish
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Eli Lilly announced positive Phase 3 results from the BRUIN CLL-322 trial showing that adding pirtobrutinib to venetoclax and rituximab significantly improved progression-free survival in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The trial enrolled patients mostly previously treated with covalent BTK inhibitors, reflecting current clinical practice. Safety profiles were consistent across treatment arms, and overall survival trends favored the pirtobrutinib combination. Lilly plans to submit these data for regulatory approval later this year, potentially expanding treatment options for CLL patients.

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