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FDA approves DECNUPAZ, first outpatient antibody-drug conjugate for rare blood cancer BPDCN

Market News
27 May 2026
PRNewsWire
View Source
Bullish
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The FDA has approved DECNUPAZ (pivekimab sunirine-pvzy), the first antibody-drug conjugate (ADC) for treating blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare and aggressive blood cancer. This approval is based on positive results from the Phase 1/2 CADENZA trial, showing significant response rates in both newly diagnosed and relapsed patients. DECNUPAZ can be administered in an outpatient setting, offering a new treatment option for patients with limited therapies. AbbVie, the developer, highlights this as a major advancement for difficult-to-treat blood cancers.

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